null
Created with Sketch. Created with Sketch.

Clinically Documented Probiotic Lactobacillus paracasei 13434

Lactobacillus paracasei DSM 13434

Patented and clinically documented strain

In order to live a rich life full of activity and wellness, we need our bodies to stay strong and healthy, especially as we age. Lactobacillus paracasei DSM 13434 supports the immune system and contribute to a healthy lifestyle throughout the adult life.

Health benefits

  • Reduces gut permeability and translocation 8
  • Supports a healthy immune system 2-4
  • Degrades dietary fibers to SCFAs, providing nutrients to the intestinal cells and to other beneficial bacteria 3-4

Figure 1. Lactobacillus paracasei DSM 13434 is a clinically supported probiotic shown to survive passage through the GI tract and attach to intestinal cells (a) and reduce gut permiability (b) support a healthy immune system (c), resulting in a well-balanced and healthy GI environment

Benefits of Lactobacillus paracasei 13434:

  1. Survives the passage through the GI-tract and attaches to intestinal cells8
    – main criterion to be active in the intestine
  2. Reduces gut permeability and translocation 8
  3. Supports a healthy immune system 2
  4. Degrades dietary fibers to SCFAs, providing nutrients to intestinal cells and to other beneficial bacteria 3-4

Supporting preclinical and clinical studies

Lactobacillus paracasei DSM 13434 has in a clinical study been shown to possess strong anti-microbial activity against pathogenic bacteria such as Salmonella spp., Helicobacter pylori, Shigella spp. and Escherichia coli 5

The anti-inflammatory activity of L. paracasei 13434 has been studied in two preclinical studies. In an osteoporosis-model, reduced levels of the pro-inflammatory peptides TNF-α and IL-1β was seen after 6 weeks of treatment 6. The other study was a model for multiple sclerosis, where the results showed delayed onset of clinical symptoms due to increased anti-inflammatory properties 7.

L. paracasei 13434 has also been shown to reduce translocation of total bacterial content and especially of Enterobacteriaceae spp. in a model of colitis8 (Figure 2)

The clinical effect on the immune system was investigated in a double-blind, placebo-controlled and randomized study, where L. paracasei 13434 was supplemented daily for two weeks 2. The results showed that L. paracasei 13434 affect several immune parameters, such as inducing IL-12 and Natural-killer T-cells (NKT-cells). It also enhanced the phagocytic activity, acting as a first-line defense function of the immune system against infectious diseases. The NKT-cells are important for the regulation of the immune-responses, and act primarily by further activation of other immune cells through the secretion of cytokines.

Another clinical study investigated the combination of L. paracasei 13434, L. fermentum and Bifidobacterium longum, to see effect of antioxidative capacity in persons infected with Helicobacter pylori 5. The results was an increased antioxidative capacity in the active group (Figure 3).

The conclusion from both previous described clinical studies are that supplementation of L. paracasei 13434 promotes a fast immune response when needed, and maintains a strong immune system over time.

1. Ahrné et al. (1998) J. Appl. Microbiol. 85:88-94.

2. Rask et al. (2013) Clin. Exp. Immunol. 172:321-332

3. Makras et al. (2005) App. Environm. Microbiol. 71:6531-6537

4. Saulnier et al. (2008) FEMS Microbiol. Ecol. 66:516-527.

5. Hütt et al. (2006) J. Appl. Microbiol. 100:1324-1332.

6. Ohlsson et al. (2014) PloS One 9(3):e92368

7. Lavasani et al. (2010) PLoS One 5;2:e9009.

8. Osman et al. (2004) Dig. Dis. Scien. 42:320-327.

9. Berggren et al. (2011) Eur. J. Nutr. 50:203-210.

10.Busch et al. (2013) Food Nutr. Sciences 4:13-20

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Lactobacillus paracasei DSM 13434 is a patent protected strain manufactured by Probi® USA