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Clinically Documented Probiotic Lactobacillus plantarum 6595

Patented and clinically documented strain

There are times when the human body needs extra care and support. In periods of intense training, antibiotic treatment or illness as well as in the process of aging, we are put under stress and may need help to stay healthy or to recover. Lactobacillus plantarum DSM 6595 has been selected for its gastro and immune supporting properties for when the body needs it the most..

Health benefits

  • Reduces gut permeability and translocation 6
  • Supports a healthy immune system 6,8,9,10
  • Survives the passage through the GI-tract and attaches to intestinal cells 1

Figure 1. Lactobacillus plantarum 6595 is clinically documented and patent protected strain. Several studies have shown that L. plantarum 6595 survives the passage through the GI tract, and attaches to the intestinal cells through a specific mannosedependent binding mechanism. The bacteria can thereby exert its effects on the intestinal wall, and the immune system.

Benefits of Lactobacillus plantarum 6595:

  1. Survives the passage through the GI-tract and attaches to intestinal cells1
    – main criterion to be active in the intestine
  2. Reduces gut permeability and translocation 6
  3. Supports a healthy immune system 6,8-10
  4. Resulting in a well-balanced GI environment

Supporting preclinical and clinical studies

Lactobacillus plantarum 6595 possess direct anti-microbial activity against pathogenic bacteria such as Listeria, E coli, Yersinia, Shigella and others 2.

Three separate preclinical studies3-5 have shown a reduced translocation and intestinal permeability in animals after addition of L. plantarum 6595. One of the studies investigated the effect of L. plantarum 6595 in oatmeal fiber vs an elemental diet (control) in an animal model of induced enterocolitis4, and found the L. plantarum 6595 to significantly decrease bacterial translocation to both blood and organs compared to control (Figure 2).

Reduced intestinal permeability was also confirmed in a clinical study where patients with acute pancreatitis had a significantly reduced bacterial translocation after intake of L. plantarum 6595 6

The anti-inflammatory effects of L. plantarum 6595 have been shown both in vitro7 and in several clinical studies 6,8-10. The incidence of infections was investigated in two separate studies, including totally 172 subjects undergoing surgical interventions. The studies were randomized, double-blind and placebo-controlled with the supplementation of 109 cfu/day 8-9. The risk of achieving infections was significantly decreased in both studies; 30% vs 10% (p=0.01) in study 1 and 45% vs 13% (p=0.02) in study 2 (Figure 3)

Following intake of L. plantarum 6595 an increased population and growth of health-promoting bacteria and suppression of possible pathogenic bacteria have been observed1,3,4. Moreover, the nutritional status of the intestinal cells is enhanced after supplementation with L. plantarum , thereby promoting an improved intestinal environment4.

1. Johansson et al. (1993) Appl. Environ. Microbiol. 59:15-20

2. Jacobsen et al. (1999) Appl. Environ. Microbiol. 65:4949-4956.

3. Adawi et al. (1999) Micr. Ecol. in Health and Disease 11:47-54

4. Mao et al. (1997) Digestive Surgery 14: 284-291.

5. White et al. (2006) Lett. Appl. Microbiol. 42:19-23

6. Olah et al. (2002) Br. J. Surg. 89:1103-1107.

7. Pathmakanthan et al. (2004) J. Gastroenterol. Hepatol. 19:166-173.

8. Rayes et al. (2002a) Nutrition 18:609-615.

9. Rayes et al. (2002b) Transplantation 15:123-127.

10. Klarin et al. (2008) Crit. Care 12:R136

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Lactobacillus plantarum DSM 6595 is a patent protected strain manufactured by Probi® USA